Lipase Inhibitor Causes And Adverse Effects - 1576 Words

Lipase inhibitor In humans, the first step in dietary fat digestion starts in the stomach with mechanical emulsification and partial TAG hydrolysis by gastric lipase, resulting in the lipolytic products DAG and free fatty acids. (CREY, Carey, Borgstrom) The remaining part of TAG digestion is brought about in the duodenal lumen by pancreatic lipase, which acts mainly on the sn-1 and sn-3 position of TAG molecules, releasing 2-MAG and free fatty acids. (Borgstrom, Mattson) Thus, inhibition of gastric and pancreatic lipases leads to substantial decrease in the absorption of dietary fats. One lipase inhibitor already approved in 1999 by FDA was Orlistat, which was later made available as an over-the-counter drug in 2007 as a weight loss aid for overweight adults under the name Alli to be used along with a reduced-calorie, low-fat diet, and exercise program. It is to be taken in the dose of 60 mg up to three times a day with each fat-containing meal. (fda) It is known to cause undesirable GI-related adverse events such as oily evacuation, flatus with discharge, oily spotting and faecal incontinence, which leads to poor patient compliance. (Finer, Sjostrom, Davidson) Although considered relatively safe, a US consumer advocacy group namely Public Citizen differed strongly in its opinion of Xenical (Orlistat 120 mg dose under prescription) and in Alli (Orlistat 60 mg dose over the counter). Dr Sidney Wolfe, Director of Public Citizen s Health Research Group, declared to the pressShow MoreRelated Diet Pills Essay examples1010 Words   |  5 Pageslose the weight desired i n a short amount of time. Consequently, the drug was found to have unpleasant adverse side effects. These are: mood changes, blurred vision, unpleasant taste or dry mouth, constipation, diarrhea, nausea, vomiting, urinary urgency, false sense of well-being. It was a non-prescription drug easily that could easily be bought by anyone until studies showed much side effects very harmful to ones health. Next and still quite popular with the public are Bankok pills. These pillsRead MoreAn Herbal Supplement Essay1933 Words   |  8 PagesHawthorn to make tea. Several in vivo and in vitro studies have been conducted to determine the effectiveness that Hawthorn has in improving cardiovascular function by vasodilating blood vessels, decreasing arterial blood pressure, and lipid lowering effects (Wang, Xiong, Feng, 2013). Hawthorn is also known to contain chemical constituents that have disease fighting properties that may help in the treatment of heart disease and fight free radical oxidation (Tassell, Kingston, Gilr oy, Lehane, FureyRead MorePrescription Medications for the Treatment of Obesity Essay2013 Words   |  9 Pages(Orlistat), a pancreatic lipase inhibitor developed by Hoffmann-LaRoche (Geneva, Switzerland), works by blocking the absorption of fat in the intestine, but can cause uncomfortable side-effects and has been linked to an increased incidence of cancer. Meridia (known as Reductil in the UK), originally developed by Knoll AG (Ludwidgshafen, Germany), is a serotonin and norepinephrine reuptake inhibitor that is thought to act on the appetite centre of the hypothalamus. However, it often causes elevated blood pressureRead MorePotent Inhibitor Of Anaplastic Lymphoma Kinase2909 Words   |  12 Pageschemical type, NME (New Molecular Entity) and given P (priority review) status.1 Requester. John Smith, MD. Division of Hematology and Oncology, Department of Internal Medicine. 2) Pharmacology and Indications:4 Pharmacology Ceritinib is a potent inhibitor of anaplastic lymphoma kinase (ALK), a tyrosine kinase involved in the pathogenesis of nonsmall cell lung cancer (NSCLC). ALK gene abnormalities due to mutations or translocations may result in expression of oncogenic fusion proteins, that alterRead MoreObesity : The Problem Of Pediatric Obesity Essay2132 Words   |  9 Pagesconsensus resolves around appropriate responses to the problem. This literature review delves into a single, highly favored approach to managing pediatric obesity: prescription medication. The paper compares and contrasts the efficacy and associated effects of the only two drugs approved by the Food and Drug Administration (FDA) for prolonged management of childhood obesity; sibutramine and orlistat. This review of pharmacological interventions for obesity management points out the drawbacks of medicationRead MoreImproving the Guidelines for Combination Therapy for Type II Diabetes Patients1975 Words   |  8 PagesMetformin is added and over a period of three months, if the patient does not reach the target A1C levels, patient can be started on two drug combinations and we have several options to do this, from sulfonylureas, TZDs ,GLP-1 Analogues, DPP-4 inhibitors and insulin. A search of literature for this combination (2) shows that there are very few clinical studies conducted with the combination of GLP 1 analogues and Insulin and in these studies it was more common to find short-acting GLP-1 RA (exenatideRead MoreThe Effects Of Prediabetes On Growth And Pubertal Development3097 Words   |  13 Pagesprediabetes. There is an increasing evidence to support the efficacy of pharmacotherapy in prevention of diabetes in adults with prediabetes. There is no report of systematic evaluation of health outcomes related to prediabetes in children. The effects of pharmacotherapy of prediabetes on growth and pubertal development in children are unknown. Secondary intervention with pharmacotherapy with metf ormin is advocated for high-risk individuals but criteria for such consideration benefit of early interventionRead MoreChildhood Obesity : An Epidemic2898 Words   |  12 Pagesearly mortality2 sooner or later in their life. Adverse effects of childhood obesity not only affect the current or later health status of children but also the country’s productivity and economy. Therefore it is very important to break the obesity viscous cycle in order to have a healthy nation. Various factors involve in the development of this multifaceted condition – â€Å"Obesity† such as individual’s genetics, environment and behaviour2. The major causes for childhood obesity in New Zealand includeRead MoreA Short Note On Diabetes And Its Effect On The Patient Severe Pain2338 Words   |  10 PagesGout is a condition of the joint that causes the patient severe pain. It is characterized by an increase of uric acid in the blood that lasts for some time. This elevation of uric acid in the blood is called hyperuricemia. In normal development, uric acid is chemical that is produced in the body. This chemical is created when the body breaks down substances called purines. Normally, uric acid dissolves in the blood and is excreted by the kidneys and passes through the urine. If the patient’sRead MorePancreatic Cancer2232 Words   |  9 Pagesplaces than if it first occurred on the head of the organ. These tumors are usually large and may be palpated, and metastases to the liver cause hepatomegaly. Cancer of the tail and body metastasis to the retroperitoneal, vertebral column, spleen, adrenal glands, colon, or stomach. Cancer of the head of the pancreas are small lesions tumors that can cause compression and impair the function of the bile duct. Regardless of the original site on the pancreas it spreads rapidly. Manifestations

Canada And The Cold War - 1514 Words

Canada and the Cold War The Cold War is a time of managed political and military coercion and turmoil between the superpowers. It was a war that actually wasn t your common war. There were numerous military aircraft flying over the nations dropping bombs, no tanks no ground troops, no really organization of rockets, and no ground troops. Then again, there were a stockpile of atomic weapons, cash was being spent like a really war was being battled, purposeful publicity, there were two superpower adversaries yet not really battling happened. The cool war was a major weapons contest that was begun after World War II between the United States and the Soviet Union. This war causes a bipolar framework on the planet where there were two†¦show more content†¦The Cold war, a threatening competition between the United States and the Soviet Unions, kept going from the late 1940 s until the breakdown of the Soviet Union in 1991. The war was icy just in that the United States and USSR never battled one another in an immediate military encounter, however both superpowers debilitated one another with atomic destruction and partook oftentimes in intermediary wars by supporting associated countries in various hot wars set up like Korea, Vietnam, and Angola. The Cold War characterized both nations outside strategies through the a large portion of the twentieth century, as the Americans and Soviets sought partners to keep up and enlarge their separate effective reaches around the globe. Every side saw the chilly war as a fight between the developments, in the overall conflict between the American free enterprise, and Soviet socialism, one and only could win. For over forty years, the Soviet-American clash hung overwhelming over worldwide issues, forming the world with gigantic military developments, an endless atomic weapons contest, serious surveillance, and furious mechanical rivalry as every side attempted to pick up the high ground in planning for the nuclear hot war all people dreaded wo uld some time or another come. Albeit both

Module discussion Free Essays

Organization Priorities Identify the current health policy priorities for your state nurses association. Identify the benefits that could come to you, your community, health care consumers in the district, and other members of the nursing profession if proposed priorities were supported. Develop a plan of action to educate your state senators and representatives about these priorities. We will write a custom essay sample on Module discussion or any similar topic only for you Order Now The Florida Nurses Association (FAN) Is Involved In a couple legislative related projects that I found on their website. Firstly, I found the Fan’s position on the expansion of Medicaid. In the document provided on their website there Is lot of background Information on Medical and how this would affect the population (FAN, 2012). While this legislative topic has already been addressed, I still thought It would be useful to discuss. I found another bill, H. R. 5113, which alms to end the Increased federal funding for Medicaid expansion with respect to Inmates hospital care under the Patient Protection and Affordable Care Act (FAN, 2014). As the FAN already supported the expansion, I find this would contradict their previously stated position on Medicaid expansion. Personally, I do think this bill should be supported. As a nurse, I cannot see the fairness of removing coverage of individuals who are inmates. To educate my state senators and representatives on my position, I would plan to write them a letter. I would write my letter Just as we did for one of our assignments. After that assignment I feel as though I can accomplish a lot more than I could before hen it comes to writing professional letters. How to cite Module discussion, Papers